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In the 18th and early 19th centuries, American art and literature took most of its cues from Europe. Writers such as Nathaniel Hawthorne, Edgar Allan Poe, and Henry David Thoreau established a distinctive American literary voice by the middle of the 19th century. Mark Twain and poet Walt Whitman were major figures in the century's second half; Emily Dickinson, virtually unknown during her lifetime, is now recognized as an essential American poet.[199] A work seen as capturing fundamental aspects of the national experience and character—such as Herman Melville's Moby-Dick (1851), Twain's The Adventures of Huckleberry Finn (1885), and F. Scott Fitzgerald's The Great Gatsby (1925)—may be dubbed the "Great American Novel."

Eleven U.S. citizens have won the Nobel Prize in Literature, most recently Toni Morrison in 1993. Ernest Hemingway, the 1954 Nobel laureate, is often named as one of the most influential writers of the 20th century.[200] Popular literary genres such as the Western and hardboiled crime fiction developed in the United States. The Beat Generation writers opened up new literary approaches, as have postmodernist authors such as John Barth, Thomas Pynchon, and Don DeLillo.

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